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Lloyd Trotman

Lloyd Trotman

Professor
Cancer Center Deputy Director of Education

Ph.D., University of Zurich, 2001

trotman@cshl.edu | 516-367-5054

Trotman Lab Website   Faculty Profile

We pioneered generation of a unique genetic mouse model for therapy and analysis of metastatic prostate cancer. Recently, we developed 3-dimensional whole organ imaging technology that allows us to visualize cancer and metastatic progression in its native environment and at single cell resolution. Now, we use this platform to understand the role of nerves in tumor metastasis, and to develop novel therapeutic interventions against lethal disease.

Understanding Metastasis–Designing models of lethal cancer

The Trotman lab have developed the RapidCaP model system to study metastatic prostate cancer in vivo. This approach allows them to visualize and probe metastasis biology in the fully native and immune competent setting. They combine this with 3D whole organ imaging at single cell resolution to define the stepwise progression from primary tumor escape to colonization of metastatic sites such as bone, liver and lung.

The Neuro-Metastasis Interface

A major challenge in metastasis research is the identification of factors that control progression of non life-threatening tumors to lethal metastatic disease. In spite of much knowledge on the role of tumor neuron interactions in primary prostate cancer, the role of neurons in metastatic prostate cancer remains to be defined. They use their whole organ imaging platform on metastatic tumors to map and manipulate interactions between the peripheral nervous system and metastatic lesions in collaboration with neuroscientists at CSHL.

Therapy of Lethal Prostate Cancer

They use the RapidCaP model to understand evolution of metastasis and therapy resistance in order to advance the 70 year old standard of care, anti-hormonal therapy, which is not curative. They combine three cutting edge approaches to test novel therapeutic concepts, in vivo: Single cell analysis of metastatic therapy resistance, dietary control of prostate cancer progression, discovery of therapeutic targets in genome wide screens.

2022 Member, AACR Science Education and Career Advancement Committee
2021 Editorial Board member, The Journal of Cell Biology, Rockefeller Press, NY
2020 Editorial Advisory Board member, The EMBO Journal
2014 Pershing Square Sohn Prize
2014 American Cancer Society Scholar
2008 V Foundation Scholar
2007 Rita Allen Foundation Scholar
2006 ASCB Merton R. Bernfield Memorial Award

See all Trotman news

All Publications

Pleiotropic tumor suppressive functions of PTEN missense mutations during gliomagenesis

20 Dec 2024 | iScience | 27(12):111278
Jun, H;  Paulo, J;  Appleman, V;  Yaron-Barir, T;  Johnson, J;  Yeo, A;  Rogers, V;  Kuang, S;  Varma, H;  Gygi, S;  Trotman, L;  Charest, A;  

Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function

25 Oct 2024 | Science | 386(6720):eadk9167
Swamynathan, Manojit;  Kuang, Shan;  Watrud, Kaitlin;  Doherty, Mary;  Gineste, Charlotte;  Mathew, Grinu;  Gong, Grace;  Cox, Hilary;  Cheng, Eileen;  Reiss, David;  Kendall, Jude;  Ghosh, Diya;  Reczek, Colleen;  Zhao, Xiang;  Herzka, Tali;  Špokaitė, Saulė;  Dessus, Antoine;  Kim, Seung;  Klingbeil, Olaf;  Liu, Juan;  Nowak, Dawid;  Alsudani, Habeeb;  Wee, Tse-Luen;  Park, Youngkyu;  Minicozzi, Francesca;  Rivera, Keith;  Almeida, Ana;  Chang, Kenneth;  Chakrabarty, Ram;  Wilkinson, John;  Gimotty, Phyllis;  Diermeier, Sarah;  Egeblad, Mikala;  Vakoc, Christopher;  Locasale, Jason;  Chandel, Navdeep;  Janowitz, Tobias;  Hicks, James;  Wigler, Michael;  Pappin, Darryl;  Williams, Roger;  Cifani, Paolo;  Tuveson, David;  Laporte, Jocelyn;  Trotman, Lloyd;  

Next Directions in the Neuroscience of Cancers Arising outside the CNS

4 Apr 2024 | Cancer Discovery | 14(4):669-673
Amit, Moran;  Anastasaki, Corina;  Dantzer, Robert;  Demir, Ihsan;  Deneen, Benjamin;  Dixon, Karen;  Egeblad, Mikala;  Gibson, Erin;  Hervey-Jumper, Shawn;  Hondermarck, Hubert;  Magnon, Claire;  Monje, Michelle;  Na'ara, Shorook;  Pan, Yuan;  Repasky, Elizabeth;  Scheff, Nicole;  Sloan, Erica;  Talbot, Sebastien;  Tracey, Kevin;  Trotman, Lloyd;  Valiente, Manuel;  Van Aelst, Linda;  Venkataramani, Varun;  Venkatesh, Humsa;  Vermeer, Paola;  Winkler, Frank;  Wong, Richard;  Gutmann, David;  Borniger, Jeremy;  

Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells

27 Feb 2024 | Cancer Cell | :S1535-6108(24)00048
Colucci, Manuel;  Zumerle, Sara;  Bressan, Silvia;  Gianfanti, Federico;  Troiani, Martina;  Valdata, Aurora;  D'Ambrosio, Mariantonietta;  Pasquini, Emiliano;  Varesi, Angelica;  Cogo, Francesca;  Mosole, Simone;  Dongilli, Cristina;  Desbats, Maria;  Contu, Liliana;  Revankdar, Ajinkya;  Chen, Jingjing;  Kalathur, Madhuri;  Perciato, Maria;  Basilotta, Rossella;  Endre, Laczko;  Schauer, Stefan;  Othman, Alaa;  Guccini, Ilaria;  Saponaro, Miriam;  Maraccani, Luisa;  Bancaro, Nicolò;  Lai, Ping;  Liu, Lei;  Pernigoni, Nicolò;  Mele, Federico;  Merler, Sara;  Trotman, Lloyd;  Guarda, Greta;  Calì, Bianca;  Montopoli, Monica;  Alimonti, Andrea;  

FABP5 Inhibition against PTEN-Mutant Therapy Resistant Prostate Cancer

2024 | Cancers | 16(1):60
Swamynathan, Manojit;  Mathew, Grinu;  Aziz, Andrei;  Gordon, Chris;  Hillowe, Andrew;  Wang, Hehe;  Jhaveri, Aashna;  Kendall, Jude;  Cox, Hilary;  Giarrizzo, Michael;  Azabdaftari, Gissou;  Rizzo, Robert;  Diermeier, Sarah;  Ojima, Iwao;  Bialkowska, Agnieszka;  Kaczocha, Martin;  Trotman, Lloyd;  

Fatty acid binding protein 5 regulates docetaxel sensitivity in taxane-resistant prostate cancer cells

2023 | PLoS ONE | 18(10):e0292483
Hillowe, Andrew;  Gordon, Chris;  Wang, Liqun;  Rizzo, Robert;  Trotman, Lloyd;  Ojima, Iwao;  Bialkowska, Agnieszka;  Kaczocha, Martin;  Pizzo, Salvatore;  

The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Aug 2023 | Nature Cancer | 4(8):1102-1121
Brina, Daniela;  Ponzoni, Adele;  Troiani, Martina;  Calì, Bianca;  Pasquini, Emiliano;  Attanasio, Giuseppe;  Mosole, Simone;  Mirenda, Michela;  D'Ambrosio, Mariantonietta;  Colucci, Manuel;  Guccini, Ilaria;  Revandkar, Ajinkya;  Alajati, Abdullah;  Tebaldi, Toma;  Donzel, Deborah;  Lauria, Fabio;  Parhizgari, Nahjme;  Valdata, Aurora;  Maddalena, Martino;  Calcinotto, Arianna;  Bolis, Marco;  Rinaldi, Andrea;  Barry, Simon;  Rüschoff, Jan;  Sabbadin, Marianna;  Sumanasuriya, Semini;  Crespo, Mateus;  Sharp, Adam;  Yuan, Wei;  Grinu, Mathew;  Boyle, Alexandra;  Miller, Cynthia;  Trotman, Lloyd;  Delaleu, Nicolas;  Fassan, Matteo;  Moch, Holger;  Viero, Gabriella;  de Bono, Johann;  Alimonti, Andrea;  

Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology

4 Apr 2023 | Analytical Chemistry | 95(13):5661-5670
Chung, Taemoon;  Garcia, Libia;  Swamynathan, Manojit;  Froeling, Fieke;  Trotman, Lloyd;  Tuveson, David;  Lyons, Scott;  

PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers

3 Dec 2022 | Molecular Oncology
Aakula, Anna;  Isomursu, Aleksi;  Rupp, Christian;  Erickson, Andrew;  Gupta, Nikhil;  Kauko, Otto;  Shah, Pragya;  Padzik, Artur;  Pokharel, Yuba;  Kaur, Amanpreet;  Li, Song-Ping;  Trotman, Lloyd;  Taimen, Pekka;  Rannikko, Antti;  Lammerding, Jan;  Paatero, Ilkka;  Mirtti, Tuomas;  Ivaska, Johanna;  Westermarck, Jukka;  

Internally-controlled and dynamic optical measures of functional tumor biology

31 May 2022 | bioRxiv
Chung, Taemoon;  Garcia, Libia;  Swamynathan, Manojit;  Froeling, Fieke;  Trotman, Lloyd;  Tuveson, David;  Lyons, Scott;  

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