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Led by CSHL Professor and Howard Hughes Medical Institute Investigator Leemor Joshua-Tor, a team used x-ray crystallography to capture the equivalent of freeze-frames of a class of enzymes called TUTases. The pictures, at the resolution of individual atoms, shows them interacting with other molecules to regulate the activity of an important small RNA molecule called let-7. The work should help advance a novel cancer treatment concept. Read more
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