Corina Amor Vegas
Assistant Professor
Cancer Center Program Co-Leader
M.D., Ph.D., Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 2021
amor@cshl.edu | 516-367-5504
As we age our body accumulates damaged “senescent” cells that our immune system is no longer able to effectively eliminate. Senescent cells are responsible for the development of aging and age-related diseases like cancer or fibrosis. My group studies how senescent cells evade the immune system thereby identifying new therapeutic approaches.
Our lab studies cellular senescence. Senescence is a stress response program that is triggered in damaged cells and leads to their elimination by the immune system. If uncleared, the accumulation of senescent cells generates a chronic pro-inflammatory microenvironment that conduces to aging and tumor development. We seek to understand how the immune system recognizes and targets these cells in physiological conditions and how senescent cells evade immune clearance in disease. We aim to leverage our findings to develop immune-based therapeutic approaches to target senescent cells in cancer, aging and age-related pathologies. In our studies we develop and combine novel somatic mouse models of cancer and cell-based therapeutics such as our recently developed senolytic CAR T cells.
Cocktails & Chromosomes: Why do we age?
July 18, 2024
Humans have asked this question since the dawn of civilization. Today, we have the answer. Find out about this and more from CSHL’s Corina Amor Vegas.
From novel discovery to anti-aging therapy
February 8, 2024
Former CSHL Fellow Carol Greider’s Nobel-winning research has led to new cancer treatments. Now, it’s helping us unravel the mysteries of aging.
A quiz for the ages
January 29, 2024
Want to know the secret to a long life? So do CSHL scientists. Take this short quiz to see what they’ve found out about aging and longevity.
The fountain of youth is … a T cell?
January 24, 2024
CSHL's Corina Amor Vegas discovers that CAR T cells can act as a “living” drug, causing young mice to age more slowly and old mice to rejuvenate.
Inside a Nobelist’s notebooks
December 13, 2023
Carol Greider’s lab writings offer a firsthand look at her Nobel Prize-winning research—work that continues today in CSHL’s Amor Vegas lab.
CSHL celebrates 50th anniversary of McClintock Laboratory
November 20, 2023
Fifty years ago, CSHL honored Barbara McClintock by dedicating a building in her name. Today, it is home to four innovative cancer labs.
President’s essay: Bringing bold visions to life
May 26, 2023
CSHL President & CEO Bruce Stillman sees the Laboratory as a global hub for scientific expertise and a powerful launchpad for early-career scientists.
MWCABC donates $75,000 to CSHL’s Dr. Corina Amor
January 18, 2023
Members of the Manhasset Women's Coalition Against Breast Cancer presented a $75,000 check to CSHL's Dr. Corina Amor to support her research.
Cold Spring Harbor Laboratory: Foundations for the Future
December 15, 2022
CSHL continues to lead in biomedical sciences by fostering a collaborative, innovative, and high-risk, high-reward research community.
Amor Vegas wins NIH Director’s Early Independence Award
October 4, 2022
The 2022 award, given to only 14 investigators, will support her pioneering research on the aging process.
All Publications
SGLT2 regulates immune-mediated senolysis
10 Jun 2024 | Nature Aging
Guo, Guangran; Amor, Corina;
eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer
11 May 2024 | bioRxiv
Boyer, Jacob; Sharma, Malvika; Dorso, Madeline; Mai, Nicholas; Amor, Corina; Reiter, Jason; Kannan, Ram; Gadal, Sunyana; Xu, Jianing; Miele, Matthew; Zhuoning, Li; Chen, Xiaoping; Chang, Qing; Pareja, Fresia; Worland, Stephan; Warner, Douglas; Sperry, Sam; Chiang, Gary; Thompson, Peggy; Yang, Guangli; Ouerfelli, Ouathek; De Stanchina, Elisa; Wendel, Hans; Rosen, Ezra; Chandarlapaty, Sarat; Rosen, Neal;
Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness
22 Mar 2024 | bioRxiv
Eskiocak, Onur; Chowdhury, Saria; Shah, Vyom; Nnuji-John, Emmanuella; Chung, Charlie; Boyer, Jacob; Harris, Alexander; Habel, Jill; Sadelain, Michel; Beyaz, Semir; Amor, Corina;
Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies.
Mar 2024 | Nature | 627(8004):E9
Amor, Corina; Feucht, Judith; Leibold, Josef; Ho, Yu-Jui; Zhu, Changyu; Alonso-Curbelo, Direna; Mansilla-Soto, Jorge; Boyer, Jacob; Li, Xiang; Giavridis, Theodoros; Kulick, Amanda; Houlihan, Shauna; Peerschke, Ellinor; Friedman, Scott; Ponomarev, Vladimir; Piersigilli, Alessandra; Sadelain, Michel; Lowe, Scott;
Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatotic liver disease
18 Mar 2024 | Journal of Hepatology | :S0168-8278(24)00197
Yashaswini, Chittampalli; Qin, Tianyue; Bhattacharya, Dipankar; Amor, Corina; Lowe, Scott; Lujambio, Amaia; Wang, Shuang; Friedman, Scott;
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
24 Jan 2024 | Nature Aging
Amor, Corina; Fernández-Maestre, Inés; Chowdhury, Saria; Ho, Yu-Jui; Nadella, Sandeep; Graham, Courtenay; Carrasco, Sebastian; Nnuji-John, Emmanuella; Feucht, Judith; Hinterleitner, Clemens; Barthet, Valentin; Boyer, Jacob; Mezzadra, Riccardo; Wereski, Matthew; Tuveson, David; Levine, Ross; Jones, Lee; Sadelain, Michel; Lowe, Scott;
Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
4 Jan 2024 | Nature Cancer
Leibold, Josef; Tsanov, Kaloyan; Amor, Corina; Ho, Yu-Jui; Sánchez-Rivera, Francisco; Feucht, Judith; Baslan, Timour; Chen, Hsuan-An; Tian, Sha; Simon, Janelle; Wuest, Alexandra; Wilkinson, John; Lowe, Scott;
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
26 Sep 2023
Amor, Corina; Fernández-Maestre, Inés; Chowdhury, Saria; Ho, Yu-Jui; Nadella, Sandeep; Graham, Courtenay; Carrasco, Sebastian; Nnuji-John, Emmanuella; Feucht, Judith; Hinterleitner, Clemens; Barthet, Valentin; Boyer, Jacob; Mezzadra, Riccardo; Wereski, Matthew; Tuveson, David; Levine, Ross; Jones, Lee; Sadelain, Michel; Lowe, Scott;
Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
15 Jun 2022 | bioRxiv
Leibold, Josef; Amor, Corina; Tsanov, Kaloyan; Ho, Yu-Jui; Sánchez-Rivera, Francisco; Feucht, Judith; Baslan, Timour; Chen, Hsuan-An; Tian, Sha; Simon, Janelle; Wuest, Alexandra; Wilkinson, John; Lowe, Scott;
Senolytic CAR T cells reverse senescence-associated pathologies.
17 Jul 2020 | Nature | 583(7814):127-132
Amor, Corina; Feucht, Judith; Leibold, Josef; Ho, Yu-Jui; Zhu, Changyu; Alonso-Curbelo, Direna; Mansilla-Soto, Jorge; Boyer, Jacob; Li, Xiang; Giavridis, Theodoros; Kulick, Amanda; Houlihan, Shauna; Peerschke, Ellinor; Friedman, Scott; Ponomarev, Vladimir; Piersigilli, Alessandra; Sadelain, Michel; Lowe, Scott;