Erika Tse-Luen Wee
Research Assistant Professor & Director, Microscopy Shared Resource
Ph.D., National Tsing Hua University, 2009
wee@cshl.edu | 516-367-5079
Faculty ProfileDevelop and implement state-of-the-art fluorescence imaging and analysis techniques to quantify cell and tissue samples' structure and function.
Develop and implement state-of-the-art fluorescence imaging and analysis techniques to quantify the molecular and cellular mechanisms of cell and tissue function to provide insights into cancer, neuroscience, and plant biology. Investigate the dynamic intricacies of cell-cell interactions, protein localization, and signaling using innovative imaging techniques. Train individuals in using advanced microscope modalities and advise researchers on the preparation of live cells, organoids, and tissue sections for advanced high-resolution 3D tissue imaging, and 4D live cell imaging to localize protein-protein and protein-nucleic-acid interactions and examine intra-cellular/tissue structures. Provide training and support for advanced software packages for advanced image processing, 3D rendering, and 4D measurements.
Selected Publications
Tissue-Like 3D Standard and Protocols for Microscope Quality Management
5 Apr 2023 | Microscopy and Microanalysis | 29(2):616-634
Abrams, Benjamin; Pengo, Thomas; Wee, Tse-Luen; Deagle, Rebecca; Vuillemin, Nelly; Callahan, Linda; Smith, Megan; Kubow, Kristopher; Girard, Anne-Marie; Rappoport, Joshua; Bayles, Carol; Cameron, Lisa; Cole, Richard; Brown, Claire;
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice
28 Sep 2022 | Nature Neuroscience
Auguste, Yohan; Ferro, Austin; Kahng, Jessica; Xavier, Andre; Dixon, Jessica; Vrudhula, Uma; Nichitiu, Anne-Sarah; Rosado, Daniele; Wee, Tse-Luen; Pedmale, Ullas; Cheadle, Lucas;
Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases
16 Nov 2021 | Cell Reports | 37(7):110027
Taranda, Julian; Mathew, Grinu; Watrud, Kaitlin; El-Amine, Nour; Lee, Matthew; Elowsky, Corey; Bludova, Anastasiia; Escobar Avelar, Sintia; Nowak, Dawid; Wee, Tse-Luen; Wilkinson, John; Trotman, Lloyd; Osten, Pavel;
Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX
7 Aug 2019 | Scientific Reports | 9(1):11430
Rajah, Abira; Boudreau, Colton; Ilie, Alina; Wee, Tse-Luen; Tang, Kaixi; Borisov, Aleksandar; Orlowski, John; Brown, Claire;
All Publications
PTPN23-dependent ESCRT machinery functions as a cell death checkpoint
28 Nov 2024 | Nature Communications | 15(1):10364
Song, Dongyan; Cen, Yuxin; Qian, Zhe; Wu, Xiaoli; Rivera, Keith; Wee, Tse-Luen; Demerdash, Osama; Chang, Kenneth; Pappin, Darryl; Vakoc, Christopher; Tonks, Nicholas;
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function
25 Oct 2024 | Science | 386(6720):eadk9167
Swamynathan, Manojit; Kuang, Shan; Watrud, Kaitlin; Doherty, Mary; Gineste, Charlotte; Mathew, Grinu; Gong, Grace; Cox, Hilary; Cheng, Eileen; Reiss, David; Kendall, Jude; Ghosh, Diya; Reczek, Colleen; Zhao, Xiang; Herzka, Tali; Špokaitė, Saulė; Dessus, Antoine; Kim, Seung; Klingbeil, Olaf; Liu, Juan; Nowak, Dawid; Alsudani, Habeeb; Wee, Tse-Luen; Park, Youngkyu; Minicozzi, Francesca; Rivera, Keith; Almeida, Ana; Chang, Kenneth; Chakrabarty, Ram; Wilkinson, John; Gimotty, Phyllis; Diermeier, Sarah; Egeblad, Mikala; Vakoc, Christopher; Locasale, Jason; Chandel, Navdeep; Janowitz, Tobias; Hicks, James; Wigler, Michael; Pappin, Darryl; Williams, Roger; Cifani, Paolo; Tuveson, David; Laporte, Jocelyn; Trotman, Lloyd;
A brain-body feedback loop driving HPA-axis dysfunction in breast cancer
14 Sep 2024 | bioRxiv
Gomez, Adrian; Wu, Yue; Zhang, Chao; Boyd, Leah; Wee, Tse-Luen; Gewolb, Joseph; Amor, Corina; Cheadle, Lucas; Borniger, Jeremy;
MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer
26 Jul 2024 | Cancer Discovery
Klingbeil, Olaf; Skopelitis, Damianos; Tonelli, Claudia; Yoshimoto, Toyoki; Alpsoy, Aktan; Panepinto, Maria; Minicozzi, Francesca; Merrill, Joseph; Cafiero, Amanda; Aggarwal, Disha; Russo, Suzanne; Ha, Taehoon; Demerdash, Osama; Wee, Tse-Luen; Spector, David; Lyons, Scott; Tuveson, David; Cifani, Paolo; Vakoc, Christopher;
SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23 (correction)
2024 | Proceedings of the National Academy of Sciences of the United States of America | 121(30)
Segovia, Danilo; Adams, Dexter; Hoffman, Nickolas; Tepes, Polona; Wee, Tse-Luen; Cifani, Paolo; Joshua-Tor, Leemor; Krainer, Adrian;
SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23
21 May 2024 | Proceedings of the National Academy of Sciences of the United States of America | 121(21):e2322974121
Segovia, Danilo; Adams, Dexter; Hoffman, Nickolas; Safaric Tepes, Polona; Wee, Tse-Luen; Cifani, Paolo; Joshua-Tor, Leemor; Krainer, Adrian;